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pentobarbital decreases levels of ponatinib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Prevent or Use Alternate Drug. Steer clear of Unless of course the coadministration outweighs the feasible hazard of ponatinib underexposure; monitor for signs of diminished efficacy.pentobarbital will lessen the extent or impact of bexarotene by i